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However, chronic excessive alcohol consumption leads to significant metabolic disruptions: (1) Disruption of the NADH/NAD + Ratio: This imbalance enhances respiratory chain activity, increases oxygen consumption, and promotes ROS formation (Yang et al., 2022)
Pay attention to any changes and adjust your regimen as necessary
However, conventional small-molecule drugs and biologic macromolecules (e.g., antibodies) exhibit extremely low delivery efficiency to the fundus, typically less than 0.01%, due to multiple barriers, including the cornea, tear drainage, and the BRB [21]
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